Which of the following is NOT a mechanism by which oral antidiabetic drugs work?

The correct answer is that increasing insulin resistance is not a mechanism by which oral antidiabetic drugs work. Oral antidiabetic medications are designed to improve blood sugar control primarily by enhancing the body's ability to utilize insulin effectively.

Improving insulin secretion helps stimulate the pancreas to produce more insulin in response to meals, while suppressing glucagon secretion reduces the amount of glucose released by the liver, which can help lower blood sugar levels. Delaying carbohydrate digestion and absorption slows the rise in blood glucose after eating, providing better overall glycemic control.

Increasing insulin resistance, however, would have the opposite effect; it would make the body's cells less sensitive to insulin, leading to higher blood glucose levels. Thus, promoting insulin resistance would not align with the goals of oral antidiabetic therapies, making it the correct answer to identify as not being a mechanism of these drugs.