How can Type II diabetes worsen over time?

In the context of Type II diabetes, the condition can indeed worsen over time primarily due to the exhaustion of beta-cells. These cells, located in the pancreas, are responsible for producing insulin. Initially, when insulin resistance occurs—where the body's cells do not respond adequately to insulin—the beta-cells compensate by producing more insulin. However, this overproduction can lead to stress and eventual burnout of these cells. Once the beta-cells are exhausted, they can no longer produce sufficient insulin to regulate blood glucose levels effectively, resulting in worsening hyperglycemia and the progression of diabetes.

This deterioration emphasizes the importance of early intervention in Type II diabetes management, which can include lifestyle changes, dietary modifications, and, when necessary, medication to preserve beta-cell function and improve insulin sensitivity. Addressing any factors contributing to insulin resistance is crucial in preventing this downward spiral.